Search for dissertations about: "HEK293"
Showing result 6 - 10 of 40 swedish dissertations containing the word HEK293.
-
6. Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1
Abstract : Cytochrome P450 is a superfamily of enzymes involved in the metabolism of endogenous and exogenous compounds. The P450 enzymes are expressed at high levels in the liver, but are also found in extrahepatic tissues and in transformed tissues. READ MORE
-
7. Tools for the development of intensified perfusion processes for mammalian cell culture
Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE
-
8. Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy
Abstract : There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce adverse drug reactions and contribute to the development of personalized medicine. READ MORE
-
9. Nephrin cellular trafficking and intracellular interactions
Abstract : Nephrin is a 180-kDa transmembrane glycoprotein belonging to the immunoglobulin family of cell adhesion molecules. Nephrin has an extracellular part with eight Ig-like motifs, one fibronectin-like domain, a transmembrane region and a short cytoplasmic tail. READ MORE
-
10. Understanding Heparan Sulfate Biosynthesis and Functional Implications of Heparanase
Abstract : Heparan sulfate (HS) proteoglycans are present on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Heparanase is an endo-ß-glucuronidase that cleaves HS chains at internally located ß-glucuronidic linkages1. READ MORE