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Showing result 1 - 5 of 16 swedish dissertations matching the above criteria.

  2. 1. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies

    Author : Ann-Charlott Steffen; Jörgen Carlsson; Vladimir Tolmachev; Lars Gedda; Ragnar Hultborn; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; HER-2; affibody; 211At; tumor targeting; targeted radiotherapy; molecular imaging; Biomedicin; Microbiology; Mikrobiologi;

    Abstract : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. READ MORE

  4. 2. Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies

    Author : Mikael Persson; Per-Uno Malmström; Vladimir Tolmachev; Jörgen Carlsson; Marion De Jong; Uppsala universitet; []
    Keywords : Molecular medicine; Neoplasm Antibodies; Targeted Radiotherapy; Radionuclide Imaging; Molekylärmedicin;

    Abstract : Targeted radionuclide therapy (TRT) holds great promise for the treatment of cancer. In TRT, radioactive nuclides are delivered specifically to tumours by molecules that recognise and bind to structures overexpressed by, or specific to, cancer cells. READ MORE

  5. 3. Predictive Factors in Esophageal Carcinoma

    Author : Martin Dreilich; Michael Bergqvist; Anders Larsson; Daniel Brattström; Gunnar Wagenius; Claes Mercke; Uppsala universitet; []
    Keywords : Oncology; Esophageal carcinoma; Survival; Prognosis; Angiogenesis; HER-2; Telomerase; FMCA; HPV; Onkologi;

    Abstract : Esophageal carcinoma is a malignancy with a poor prognosis and is the sixth cause of cancer related death worldwide. In Sweden approximately 400 new cases are diagnosed every year. The aim of this present thesis was to investigate predictive factors for esophageal carcinoma patients. READ MORE

  6. 4. Tumor Cell Targeting of Stabilized Liposome Conjugates : Experimental studies using boronated DNA-binding agents

    Author : Erika Bohl Kullberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; Liposome; EGF; HER-2; Targeting; boron; Biomedicin; Microbiology; Mikrobiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : To further develop cancer therapy, targeted delivery of cell killing agents directly to tumor cells is an interesting approach. This thesis describes the development of PEG-stabilized liposome conjugates targeting either epidermal growth factor receptor (EGFR) using its natural ligand EGF, or human epidermal growth factor receptor 2 (HER-2) using the antibody trastuzumab. READ MORE

  7. 5. Prognostic Factors in Early Stages (FIGO I-II) of Epithelial Ovarian Carcinoma

    Author : Ingirídur Skírnisdóttir; Seija Grenman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Ovarian cancer; early stages; adjuvant therapy; prognosis; tumor grade; apoptotic regulators; p53; bcl-2; bax; growth factor receptors; HER-2 neu; EGFR; DNA ploidy; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

    Abstract : From January, 1988, to December, 1993, 113 patients with FIGO stage IA-IIC epithelial ovarian carcinoma were treated with postoperative radiotherapy. The median follow-up period was 74 months. Tumor recurrences were recorded in 33 cases (30%). The cancer-specific survival rate was 72%. READ MORE