Search for dissertations about: "HER2"

Showing result 21 - 25 of 102 swedish dissertations containing the word HER2.

  1. 21. Methods for Generation and Characterization of Monospecific Antibodies

    University dissertation from Stockholm : KTH

    Author : Johan Rockberg; Mathias Uhlén; John McCafferty; [2008]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody; epitope mapping; HER2; human protein atlas; immunogenicity; proteomics; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik;

    Abstract : Recent advances in biotechnology have generated possibilities to investigate and measure parts of life previously left for believers to explain. Utilizing the same book of recipes, the genome, our cells produce selections of proteins at a time and thereby niche into a multitude of specialized cell types, tissues and organs comprising our body. READ MORE

  2. 22. Novel Methods for Analysis of Heterogeneous Protein-Cell Interactions Resolving How the Epidermal Growth Factor Binds to Its Receptor

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hanna Björkelund; Karl Andersson; Lars Gedda; Yosef Yarden; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heterogeneity; Kinetics; EGFR; HER2; LigandTracer; Interaction Map; Internalization; Specificity; Medical Science; Medicinsk vetenskap;

    Abstract : Cells are complex biological units with advanced signalling systems, a dynamic capacity to adapt to its environment, and the ability to divide and grow. In fact, they are of such high level of complexity that it has deemed extremely difficult or even impossible to completely understand cells as complete units. READ MORE

  3. 23. Utilizing Solid Phase Cloning, Surface Display And Epitope Information for Antibody Generation and Characterization

    University dissertation from KTH Royal Institute of Technology

    Author : Francis Jingxin Hu; Johan Rockberg; John McCafferty; [2017]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody engineering; antibody affinity maturation; combinatorial protein engineering; epitope mapping; FACS; HER2; complement C5; Staphylococcal surface display; surface display.; Biotechnology; Bioteknologi;

    Abstract : Antibodies have become indispensable tools in diagnostics, research and as therapeutics. There are several strategies to generate monoclonal antibodies (mAbs) in order to avoid the drawbacks of polyclonal antibodies (pAbs) for therapeutic use. READ MORE

  4. 24. Biological markers in breast cancer and acute leukaemia with focus on drug resistance

    University dissertation from Örebro : Örebro universitet

    Author : Elisabet Tina; Ulf Tidefelt; Sten Wingren; Mats G. Karlsson; Jan-Ingvar Jönsson; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; acute leukaemia; drug resistance; toposiomerase IIa; BCRP; HER2; SLC25A43; flow cytometry; real time PCR; whole genome screening; MEDICINE; MEDICIN; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Biomedicin; Biomedicine;

    Abstract : .... READ MORE

  5. 25. The HER2/neu oncoprotein and dendritic cells in immunity against tumors

    University dissertation from Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Author : Yang Rongcun; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 neu; dendritic cells; ovarian carcinoma; apoptosis;

    Abstract : It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T lymphocytes (CTLs). A number of tumor antigens recognized by CTLs on human melanomas have been defined, but less is known about antigens from other tumor types. READ MORE