Search for dissertations about: "HER3"

Showing result 1 - 5 of 11 swedish dissertations containing the word HER3.

  1. 1. Affibody molecules targeting HER3 for cancer therapy

    University dissertation from KTH Royal Institute of Technology

    Author : Tarek Bass; KTH.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecule; cancer therapy; epidermal growth factor receptors; ErbB3; HER3; protein engineering;

    Abstract : The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. READ MORE

  2. 2. Generation and characterization of Affibody molecules targeting HER3

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Magdalena Malm; KTH.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Abstract : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. READ MORE

  3. 3. Affibody Molecules for HER3-targeted Theranostics of Malignant Tumours

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Rosestedt; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affibody molecules; theranostics; HER3; molecular imaging;

    Abstract : The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. READ MORE

  4. 4. Cellular Studies of HER-family Specific Affibody Molecules

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lovisa Göstring; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE

  5. 5. HER3 expression and prognosis in colon and rectal cancer

    University dissertation from Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Author : Frida Lédel; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer;

    Abstract : In Sweden, about 6000 patients get a colorectal cancer diagnosis annually. Advances in management of both colon and rectal cancer have reduced mortality even though the incidences are increasing. READ MORE