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Showing result 1 - 5 of 15 swedish dissertations matching the above criteria.
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1. Affibody molecules targeting HER3 for cancer therapy
Abstract : The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. READ MORE
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2. Generation and characterization of Affibody molecules targeting HER3
Abstract : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. READ MORE
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3. Affibody Molecules for HER3-targeted Theranostics of Malignant Tumours
Abstract : The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. READ MORE
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4. Affibody-Based Molecular Imaging and Targeted Therapy of HER3-Expressing Cancer
Abstract : The human epidermal growth factor receptor type 3 (HER3) is overexpressed in different types of cancer and is a known contributor to disease progression and resistance to cancer therapy. This thesis is based on five original articles, which aimed to improve the diagnostic and therapeutic potential of affibody-based agents for management of HER3-expressing cancers. READ MORE
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5. Targeting Human Epidermal Growth Factor Receptors with Drug Conjugates Based on Affibody Molecules
Abstract : Cancer is a major public health challenge and the second leading cause of death in the world, with millions of new cases being diagnosed each year. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy are many times effective, but may also cause damage to healthy cells, leading to side effects. READ MORE