Search for dissertations about: "HER3"
Showing result 6 - 10 of 15 swedish dissertations containing the word HER3.
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6. Cellular Studies of HER-family Specific Affibody Molecules
Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE
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7. HER3 expression and prognosis in colon and rectal cancer
Abstract : In Sweden, about 6000 patients get a colorectal cancer diagnosis annually. Advances in management of both colon and rectal cancer have reduced mortality even though the incidences are increasing. READ MORE
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8. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy
Abstract : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. READ MORE
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9. Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging
Abstract : Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. READ MORE
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10. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy
Abstract : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. READ MORE