Search for dissertations about: "HES-1"
Showing result 1 - 5 of 8 swedish dissertations containing the word HES-1.
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1. Hormonal regulation of HES-1 in breast cancer cells
Abstract : Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis and hematopoiesis. HES-1 has several well conserved domains, from Drosophila to mammals, and is expressed in a variety of tissues, in both embryos and adults. READ MORE
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2. bHLH transcription factors in differentiating neuroblastoma cells
Abstract : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. READ MORE
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3. Transcriptional regulation in neuroblastoma cells under normoxic and hypoxic conditions
Abstract : The childhood malignancy neuroblastoma develops from early cells of the sympathetic nervous system (SNS), and the tumors often produce catecholamines. Neuroblastoma cells retain several characteristics of immature sympathetic cells including the expression of a number of transcription factors normally expressed during embryogenesis. READ MORE
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4. Notch Signaling in Human Neuroblastoma Cells
Abstract : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. READ MORE
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5. Antiproliferative action of estrogen receptor beta and Hes-1 in breast cancer
Abstract : Breast cancer is the most common malignancy among Swedish women. Although the mechanism behind the tumorigenesis remains unclear, estrogen receptor a (ERa) plays an important role in the progression of breast cancer and is regarded as a target for endocrine therapy. READ MORE