Search for dissertations about: "HES1"

Showing result 1 - 5 of 12 swedish dissertations containing the word HES1.

  2. 1. Pancreatic Endocrine Tumourigenesis : Genes of potential importance

    Author : Térèse A. Johansson; Barbro Eriksson; Britt Skogseid; Gunnar Westin; Martin Bäckdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic endocrine tumour; Multiple endocrine neoplasia type 1; Tumourigenesis; Notch signalling; Notch1; Hes1; Neurog3; Neurod1; Men1; Ascl1; Pou3f4; Pdx1; Rpl10; Dlk1; Dkk1; Tph1; menin; Tumour biology; Tumörbiologi;

    Abstract : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. READ MORE

  4. 2. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    Author : Reshma Sundar; Marene Landström; Carl-Henrik Heldin; Petra Knaus; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Abstract : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. READ MORE

  5. 3. Transcriptional networks in neuroblastoma and breast cancer

    Author : Christina Manetopoulos; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; basic helix-loop-helix; Neuroblastoma; Breast cancer;

    Abstract : Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. READ MORE

  6. 4. Regulation of cellular responses to hypoxia by HIF-1alpha-dependent and -independent signaling pathways

    Author : Xiaofeng Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hypoxia is a state of inadequate oxygen supply to the cells and tissues of the body. It plays a critical role in embryonic development, as well as in various physiological and pathological processes. READ MORE

  7. 5. Invasion and Proliferation in Malignant Cells

    Author : Sofie Svensson Månsson; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; breast cancer; squamous cell carcinoma; basal cell carcinoma; p16; proliferation; invasion; Cytologi; onkologi; cancer;

    Abstract : Two key events in the oncogenic process of tumor cells are to acquire uncontrolled proliferation and invasive properties. This allows the tumor to grow and invade beyond the tissue from which the tumor cells originate. READ MORE