Search for dissertations about: "HGH"

Showing result 1 - 5 of 10 swedish dissertations containing the word HGH.

2. 1. Monoclonal antibodies to human growth hormone : characterization, quantitation and isolation of hGH variants

   Author : Ingileif Jónsdóttir; Stockholms universitet; []
   Keywords : ;

   Abstract : .... READ MORE

4. 2. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

   Author : Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
   Keywords : Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

   Abstract : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. READ MORE

5. 3. Preparation of Pharmaceutical Powders using Supercritical Fluid Technology : Pharmaceutical Applications and Physicochemical Characterisation of Powders

   Author : Sitaram Velaga; Johan Carlfors; Kristiina Järvinen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Supercritical fluid; Gas Anti-Solvent; SEDS; Crystallisation; Particle design; Polymorphs; Dry powder inhalation; Solid-state behaviour; Therapeutic proteins; Precipitation; Stability; Recombinant human growth hormone hGH ; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : The main aim of the thesis was to explore the potential of supercritical fluid (SF) techniques in the field of drug delivery. In particular, the relatively recently developed solution-enhanced dispersion by supercritical fluids (SEDS) technology has been employed in the preparation of particles/powders. READ MORE

6. 4. Critical paediatric bioethics and the treatment of short stature : an interdisciplinary study

   Author : Maria Cristina Murano; Kristin Zeiler; Patrice Bourdelais; Bjørn Hofmann; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; critical paediatric bioethics; growth hormone treatment; medicalisation; phenomenology of the body; critical disability studies; short stature; drug regulations;

   Abstract : Several studies have argued that there is a correlation between short stature and negative experiences and characteristics, such as social discrimination, economic disadvantage, health problems (especially for men). The idea that short men have a disadvantage in social interactions and in partner choices is also widespread in popular culture and common knowledge. READ MORE

7. 5. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

   Author : Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. READ MORE