Search for dissertations about: "HGSC"
Showing result 1 - 5 of 7 swedish dissertations containing the word HGSC.
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1. Mechanisms for immune escape in epithelial ovarian cancer
Abstract : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. READ MORE
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2. Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes
Abstract : Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. READ MORE
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3. Cancer stem cells and homologous recombination deficiency in serous ovarian and endometrial carcinoma
Abstract : .... READ MORE
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4. Receptor tyrosine kinase signaling and extracellular matrix cues in ovarian cancer metastasis and drug resistance
Abstract : Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma (HGSC), the exact supporting mechanisms are still not fully understood, and the disease remains a clinical challenge with low 5-year survival and high recurrence rate. The purpose of this thesis was to study the dynamic communication between the cancer cells and the tumor microenvironment (TME) to understand how these influence and are affected by disease progression and chemotherapy in the context of HGSC. READ MORE
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5. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity
Abstract : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). READ MORE