Search for dissertations about: "HIF-1 alpha"

Showing result 1 - 5 of 8 swedish dissertations containing the words HIF-1 alpha.

2. 1. Hypoxia inducible factor-1α in renal cell carcinoma

   Author : Anders Lidgren; Börje Ljungberg; Torgny Rasmuson; Kjell Grankvist; Anders Bergh; Per-Uno Malmström; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal cell carcinoma; hypoxia; RT-PCR; angiogenesis; western blot; tissue microarray; protein; mRNA; HIF-1 alpha; GLUT-1; survival; Urology and andrology; Urologi och andrologi;

   Abstract : Hypoxia Inducible Factor-1α in Renal Cell Carcinoma Departments of Surgical and Perioperative Sciences, Urology and Andrology; Radiation Sciences, Oncology; Medical Biosciences, Pathology; and Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all human cancers. A distinguished feature of RCC is vascularisation and among the three dominating RCC types conventional RCC (cRCC) generally is more vascularised than papillary RCC (pRCC) and chromophobe RCC (chRCC). READ MORE

4. 2. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

   Author : Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

   Abstract : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. READ MORE

5. 3. Mechanisms of activation of the hypoxia-inducible transcription factor 1a

   Author : Sallyann O'Brien; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors HIF-1 alpha and HIF 1 beta/ARNT. Under hypoxic conditions HIF-1 becomes activated and transcriptionally upregulates a set of target genes involved in angiogenesis, erythropoesis and glycolysis. READ MORE

6. 4. Translational studies on mitochondrial function and hypoxia in complications of diabetes mellitus

   Author : Cheng Xu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DMassociated morbidity and mortality is mediated by diabetic complications. Hypoxia and oxidative stress have emerged as key players in the pathogenesis of various macro- and microvascular complications of DM. READ MORE

7. 5. Regulators of angiogenesis in diabetes and tumors

   Author : Sergiu-Bogdan Catrina; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Diabetes; HIF; hypoxia; tumors; growth factors; wound healing;

   Abstract : Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular energy level and the potential risk of cellular oxidative damage. READ MORE