Search for dissertations about: "HIF-1alpha"
Showing result 1 - 5 of 15 swedish dissertations containing the word HIF-1alpha.
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1. Analysis of HIF-1alpha degradation and function
Abstract : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. READ MORE
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2. Oxygen-dependent regulation of HIF-1alpha expression and function
Abstract : Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. READ MORE
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3. Expression, regulation and fuction of small ubiquitin-related modifier-1. Interaction with nuclear proteins in vivo
Abstract : The small ubiquitin-related modifier-1 (SUMO-1) is a 101-amino acid, ~12 kDa protein that is 18% identical to ubiquitin. Posttranslational covalent tagging of proteins with SUMO-1 (SUMOylation) serves many functions. For example, regulation of protein stability and modulation of transcriptional activation. READ MORE
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4. The role of HIF-1alpha in epigenetic regulation of transcription
Abstract : The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating HIF protein stability. READ MORE
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5. Assessment of HIF-1alpha function and identification of a novel degradation mechanism
Abstract : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF-1alpha and ARNT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. READ MORE