Search for dissertations about: "HIF-2"

Showing result 1 - 5 of 6 swedish dissertations containing the word HIF-2.

  2. 1. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Author : Sofie Mohlin; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Abstract : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. READ MORE

  4. 2. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

    Author : Karolina Helczynska; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Hypoxia; Breast cancer; Breast; HiF-1; HiF-2; 3D-cultures; prognosis;

    Abstract : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. READ MORE

  5. 3. Transcriptional regulation in neuroblastoma cells under normoxic and hypoxic conditions

    Author : Annika Jögi; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; HIF-2; HIF-1; hypoxia; Id; HES-1; bHLH; Neuroblastoma; neuronal differentiation;

    Abstract : The childhood malignancy neuroblastoma develops from early cells of the sympathetic nervous system (SNS), and the tumors often produce catecholamines. Neuroblastoma cells retain several characteristics of immature sympathetic cells including the expression of a number of transcription factors normally expressed during embryogenesis. READ MORE

  6. 4. Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma

    Author : Matilda Thorén; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small cell lung carcinoma; arsenic trioxide; hypoxia; hypoxia-inducible factors; survival; proliferation; glycolysis; glutamine metabolism; MYC;

    Abstract : Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. READ MORE

  7. 5. Regulators of angiogenesis in diabetes and tumors

    Author : Sergiu-Bogdan Catrina; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Diabetes; HIF; hypoxia; tumors; growth factors; wound healing;

    Abstract : Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular energy level and the potential risk of cellular oxidative damage. READ MORE