Search for dissertations about: "HIF-2alpha"

Found 3 swedish dissertations containing the word HIF-2alpha.

  2. 1. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

    Author : Alexander Pietras; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

    Abstract : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. READ MORE

  4. 2. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Author : Sofie Mohlin; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Abstract : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. READ MORE

  5. 3. Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells

    Author : Tobias Löfstedt; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Biomedicinska vetenskaper; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; Biomedical sciences; MXI1; ID2; differentiation; HIF; hypoxia; transcription; cancer; neuroblastoma; Cytologi; onkologi;

    Abstract : Cancer is a major cause of human morbidity and mortality, and the risk of developing cancer is about one in three life times. Neuroblastoma is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. READ MORE