Search for dissertations about: "HILIC Chromatography"

Showing result 1 - 5 of 9 swedish dissertations containing the words HILIC Chromatography.

  1. 1. Hydrophilic Separation Materials for Liquid Chromatography

    Author : Petrus Hemström; Knut Irgum; Peter Schoenmakers; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chromatography; HILIC; Hydrophilic; Stationary phase; Chemistry; Kemi;

    Abstract : The main focus of this thesis is on hydrophilic interaction chromatography (HILIC) and the preparation of stationary phases for HILIC. The mechanism of HILIC is also discussed; a large part of the discussion has been adapted from a review written by me and professor Irgum for the Journal of Separation Science (ref 34). READ MORE

  2. 2. Development of analytical methods for the determination of the small molecule component of complex biological systems

    Author : Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. READ MORE

  3. 3. Investigations of the retention mechanisms in hydrophilic interaction chromatography

    Author : Ngoc Phuoc Dinh; Knut Irgum; Andrew J. Alpert; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; HILIC; hydrophilic interaction chromatography; adsorption isotherm; water enriched layer; multivariate data analysis; retention mechanism; separation; analytisk kemi; Analytical Chemistry;

    Abstract : Hydrophilic interaction chromatography is well known as a powerful technique separation of polar and ionizable compound nowadays. However the retention mechanism of the technique is still under debate. Understanding retention mechanism would facilitate the method development using the technique and its future improvement. READ MORE

  4. 4. Study of retention mechanisms in Hydrophilic Interaction Chromatography by Nuclear Magnetic Resonance Spectroscopy

    Author : Adel Shamshir; Knut Irgum; Tobias Jonsson; Ngoc Phuoc Dinh; Torgny Fornstedt; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; HILIC; hydrophilic interaction chromatography; adsorption; STD-NMR; saturation transfer difference; retention mechanism; NMRD; solid state-NMR; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis deals with investigations of the retention mechanisms in hydrophilic interaction liquid chromatography (HILIC) using nuclear magnetic resonance spectroscopy. The aims are to understand how the different types of stationary phases can influence the retention of various solutes and the adsorption abilities of solvent on stationary phases. READ MORE

  5. 5. Polyhydroxyl and Polyphosphorylcholine functionalized Silica for Hydrophilic interaction liquid Chromatography- Synthesis, characterization and application

    Author : Nhat Thi Hong Bui; Knut Irgum; Michael Lämmerhofer; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Hydrophilic Interaction Chromatography; HILIC; silica; TRIS; acrylamide acrylate; ATRP; iniferter; “controlled living’’ radical polymerization; N; N′-methylenebisacrylamide; MPC; stationary phase; analytisk kemi; Analytical Chemistry;

    Abstract : This thesis focuses on the development of new stationary phases for use in hydrophilic interaction liquid chromatography using TRIS-based and phosphorylcholine typed monomers and porous silica particles as starting substrates. In this thesis, several ways of polymerizing highly hydrophilic mono­mers onto pore surfaces of silica supports are described, based on several “grafting from” schemes. READ MORE