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Showing result 1 - 5 of 9 swedish dissertations matching the above criteria.
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1. Hydrophilic Separation Materials for Liquid Chromatography
Abstract : The main focus of this thesis is on hydrophilic interaction chromatography (HILIC) and the preparation of stationary phases for HILIC. The mechanism of HILIC is also discussed; a large part of the discussion has been adapted from a review written by me and professor Irgum for the Journal of Separation Science (ref 34). READ MORE
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2. Development of analytical methods for the determination of the small molecule component of complex biological systems
Abstract : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. READ MORE
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3. Investigations of the retention mechanisms in hydrophilic interaction chromatography
Abstract : Hydrophilic interaction chromatography is well known as a powerful technique separation of polar and ionizable compound nowadays. However the retention mechanism of the technique is still under debate. Understanding retention mechanism would facilitate the method development using the technique and its future improvement. READ MORE
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4. Study of retention mechanisms in Hydrophilic Interaction Chromatography by Nuclear Magnetic Resonance Spectroscopy
Abstract : This thesis deals with investigations of the retention mechanisms in hydrophilic interaction liquid chromatography (HILIC) using nuclear magnetic resonance spectroscopy. The aims are to understand how the different types of stationary phases can influence the retention of various solutes and the adsorption abilities of solvent on stationary phases. READ MORE
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5. Polyhydroxyl and Polyphosphorylcholine functionalized Silica for Hydrophilic interaction liquid Chromatography- Synthesis, characterization and application
Abstract : This thesis focuses on the development of new stationary phases for use in hydrophilic interaction liquid chromatography using TRIS-based and phosphorylcholine typed monomers and porous silica particles as starting substrates. In this thesis, several ways of polymerizing highly hydrophilic monomers onto pore surfaces of silica supports are described, based on several “grafting from” schemes. READ MORE