Search for dissertations about: "HIV-1 DNA"

Showing result 1 - 5 of 77 swedish dissertations containing the words HIV-1 DNA.

  2. 1. Enhancement of HIV-1 DNA immunogens

    Author : Anne Kjerrström Zuber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; DNA vaccination; regulatory genes; adjuvants; experimental HIV-1 model;

    Abstract : Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. READ MORE

  4. 2. On HIV-1 latency and viral reservoirs

    Author : Tomas Mellberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; Latency; Intravenous immunoglobulin; residual viremia; low level viremia; Ultrasensitive PCR methods; Central nervous system;

    Abstract : HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir. READ MORE

  5. 3. Significance of HIV-1 genetic subtypes

    Author : Annette Alaeus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; genetic subtypes; molecular epidemiology; disease progression; CD4 cell decline; plasma RNA levels; chemokine coreceptor usage;

    Abstract : The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier) and group N (non-M-non-O). READ MORE

  6. 4. HIV-1 reverse transcriptase activity assays based on monoclonal antibodies to native enzyme : Applications on studies of antiviral substances and immunological variation of reverse transcriptase

    Author : Ann-Sofie Rytting; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; HIV-1; reverse transcriptase; monoclonal antibody; activity assay; subtype; RT inhibitor; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Specific detection of HIV-1 reverse transcriptase (RT) activity in crude materials was enhanced using a capture assay for immunopurification and subsequent activity assay. The purification step was achieved by anti-HIV-1 RT monoclonal antibodies (Mabs) immobilized onto a solid carrier. READ MORE

  7. 5. Regulation of HIV-1 provirus transcription

    Author : Mojgan H Naghavi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Key words- HIV-1; LTR; transcription; subtypes; phylogenetic analysis; NFkappaB; USF; MCEF; HMG-1 DSP1; Dorsal.;

    Abstract : Transcription of the HIV-genome is regulated by the interaction of viral long terminal repeat (LTR) cis-acting sequences with a complex of viral regulatory proteins and cellular transcription factors. The complex interplay between the cellular-, and/or viral proteins and LTR of different subtypes may play a role in the control of HIV-1 latency versus activation. READ MORE