Search for dissertations about: "HLA graft-versus-host"

Showing result 1 - 5 of 20 swedish dissertations containing the words HLA graft-versus-host.

2. 1. Stem cell transplantation : home care, graft-versus-host disease and costs

   Author : Britt-Marie Svahn; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Stem-cell transplantation; home-care; GVHD; costs;

   Abstract : Allogeneic stem-cell transplantation (ASCT) is used to treat malignant and non-malignant diseases of the immunohematopoietic system. Results in terms of survival rate and less complications are continually improving due to better knowledge, supportive care, immunosuppression, new drugs against infections and HLA-typing techniques. READ MORE

4. 2. HLA and KIR gene polymorphism in hematopoietic stem cell transplantation

   Author : Marie Schaffer; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HLA; KIR; NK cells; hematopoietic stem cell transplantation; unrelated donor;

   Abstract : The major histocompatibility complex (MHC) in humans known as the Human Leukocyte Antigens (HLA) is localised to the short arm of chromosome six. The HLA class 1 antigens, HLA-A, -B and -C are highly polymorphic glycoproteins expressed on the cell surface of most nucleated cells in the body. READ MORE

5. 3. HLA polymorphism : genomic typing and impact on unrelated stem cell transplantation

   Author : Anna Aldener-Cannavá; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The HLA (Human Leukocyte Antigen) region is the most polymorphic in the human genome. The extended polymorphism contributes to the ability both of individuals and populations to combat diversity in the pathogens to which they are exposed. READ MORE

6. 4. Immune modulation by mesenchymal stem cells

   Author : Ida Rasmusson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Mesenchymal stem cells; T cells; cytotoxic T lymphocytes; cytokines; mixed lymphocyte culture; B cells; antibody production; stem cell transplantation; acute graft versus host disease;

   Abstract : Mesenchymal stem cells (MSCs) were discovered as adherent cells in the bone marrow stroma that could form bone and stimulate hematopoiesis. Later, MSCs were shown to be hypoimmunogenic and to suppress proliferation of activated T cells. READ MORE

7. 5. Immune repertoire diversity in allogeneic stem cell transplantation and its implications for infections and the graft versus leukemia effect

   Author : Andreas Björklund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The beneficial graft versus leukemia effect (GVL) and its detrimental counterparts, graft versus host disease (GVHD) and susceptibility to infections, are all coupled to a multitude of events during the immune reconstitution (IR) after hematopoietic stem cell transplantation (HSCT). The general aim of this thesis has been to learn more about the IR in HSCT with a particular focus on the impact of infections, natural killer (NK) cell mediated GVL effects and the possibility to apply GVL effects in adoptive cell therapy. READ MORE