Search for dissertations about: "HLA-DQA1"

Found 4 swedish dissertations containing the word HLA-DQA1.

  2. 1. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

    Author : Ewa Lavant; Malmö högskola; []
    Keywords : HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

    Abstract : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. READ MORE

  4. 2. Aspects of ZnT8 autoimmunity in childhood type 1 diabetes

    Author : Cecilia K Andersson; Pediatrisk endokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Zinc transporter; ZnT8 autoantibodies; HLA; islet cell autoantibodies; GAD65 autoantibodies; IA-2 autoantibodies; insulin autoantibodies; glucose tolerance;

    Abstract : Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. READ MORE

  5. 3. Genetic association studies in allergic rhinitis

    Author : Daniel Carlberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Allergic rhinitis (AR) is a global health problem that causes major disability worldwide. Nasal obstruction, secretion and itching are characterizing features of the disease. The development and severity of AR are determined by a complex interaction between environmental and genetic factors and the heritability for AR has been estimated to be high. READ MORE

  6. 4. Human herpesvirus-6 in multiple sclerosis : assay development, immune responses and host genetics

    Author : Rasmus Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : MS is a chronic inflammatory demyelinating disease of the CNS that implies impaired motor- and cognitive functions. Life expectancy is not severely affected but the disease has substantial negative effects on the quality of life of patients and their relatives. READ MORE