Search for dissertations about: "HLA-DRB1*"

Showing result 1 - 5 of 68 swedish dissertations containing the word HLA-DRB1*.

  2. 1. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

    Author : Ewa Lavant; Malmö högskola; []
    Keywords : HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

    Abstract : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. READ MORE

  4. 2. Immunogenetic studies of multiple sclerosis

    Author : Arturs Ligers; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; CTLA-4; HLA-A2; HLA-A3; HLA-DRB1*15; HLA-DRB1*;

    Abstract : Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Several genetic factors are likely to be of importance for MS rather than one factor. READ MORE

  5. 3. Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study

    Author : Henrik Källberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Rheumatoid arthritis; HLA-DRB1; PTPN22; smoking; alcohol; case control; interaction;

    Abstract : Rheumatoid arthritis (RA) is a complex disease with autoimmune features primarily causing destruction in the joints of the body. Knowledge regarding risk indicators and causes are increasing but so far only a few genetic and very few environmental risk factors have been consistently identified. READ MORE

  6. 4. T lymphocytes in Wegener’s granulomatosis

    Author : Ricardo Antonio Giscombe Stephen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Wegener s granulomatosis; T lymphocytes; TCR; T cell expansions; HLA-DRB1*0401; CTLA-4; IL-10;

    Abstract : Wegener's granulomatosis (WG) is a systemic necrotizing vasculitis that affects small and medium size blood vessels. The respiratory tract and lungs are usually compromised with necrotizing granulomatous formations. The aetiology is unknown and untreated the prognosis of generalised WG is very poor. READ MORE

  7. 5. Studies of different clinical manifestations of Sarcoidosis and the role of genetic factors

    Author : Pernilla Darlington; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Sarcoidosis is a systemic disease of unknown etiology characterized by the formation of non-necrotizing granulomas in the affected organs. Engagement of the lungs and/or thoracic lymph nodes (LN) are found in more than 90 % of all cases, but almost any organ such as the eyes, skin, heart and nervous system can be involved. READ MORE