Search for dissertations about: "HLA"

Showing result 1 - 5 of 389 swedish dissertations containing the word HLA.

  1. 1. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

    Author : Ewa Lavant; Malmö högskola; []
    Keywords : HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

    Abstract : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. READ MORE

  2. 2. Fault-tolerance in HLA-based distributed simulations

    Author : Martin Eklöf; Rassul Ayani; Gary Tan; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; HLA; fault-tolerance; distributed simulations; federate; federation; Computer engineering; Datorteknik;

    Abstract : Successful integration of simulations within the Network-Based Defence (NBD), specifically use of simulations within Command and Control (C2) environments, enforces a number of requirements. Simulations must be reliable and be able to respond in a timely manner. Otherwise the commander will have no confidence in using simulation as a tool. READ MORE

  3. 3. HLA and disease : studies in patients with arthritis, diabetes, inflammatory bowel diseases, kidney stone disease and myasthenia gravis

    Author : Jan Säfwenberg; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 4. Human leukocyte antigen in sickness and in health : Ankylosing spondylitis and HLA in Sweden

    Author : Jessika Nordin; Kerstin Lindblad-Toh; Jennifer Meadows; Matthew Webster; Alison Meynert; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Disease genetics; Ankylosing spondylitis; HLA typing; Imputation; Inference; Sex-stratified; HLA-B*27 independent; Association tests; Functional validation; Bioinformatics; Bioinformatik; Molekylär genetik; Molecular Genetics;

    Abstract : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. READ MORE

  5. 5. Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort

    Author : Sara Björck; Diabetes och celiaki; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone mineral density; inflammation; cytokine; screening; HLA; tissue transglutaminase antibody; children; Celiac disease; vitamin D; parathyroid hormone;

    Abstract : Objectives: Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering screening a method for identification. READ MORE