Search for dissertations about: "HLH proteins"

Showing result 1 - 5 of 9 swedish dissertations containing the words HLH proteins.

  2. 1. Functional collaboration between HLH transcription factors in B cell development

    Author : Ramiro Gisler; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Abstract : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. READ MORE

  4. 2. Genetic, cellular and clinical studies of hemophagocytic lymphohistiocytosis

    Author : Marie Meeths; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyperinflammatory condition characterized by fever, cytopenia, hepatosplenomegaly, and sometimes hemophagocytosis. HLH is typically divided into two distinct groups, primary HLH and secondary HLH. READ MORE

  5. 3. Regulation and functions of basic helix-loop-helix transcription factors in neuroblastoma cells

    Author : Paula Persson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; Id; Olf EBF; ubiquilin-1; HASH-1; bHLH; Neuroblastoma; neuronal differentiation; cancer; onkologi; cancerology; Cytologi;

    Abstract : Neuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. READ MORE

  6. 4. Genetic predisposition to immune cell malfunction and inflammation

    Author : Lamberto J Torralba-Raga; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds and physical barriers, that protects us from invading pathogens. READ MORE

  7. 5. Transcriptional networks in neuroblastoma and breast cancer

    Author : Christina Manetopoulos; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; basic helix-loop-helix; Neuroblastoma; Breast cancer;

    Abstract : Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. READ MORE