Search for dissertations about: "HMG-CoA reductase"

Showing result 1 - 5 of 18 swedish dissertations containing the words HMG-CoA reductase.

  1. 1. Pleiotropic Effects of HMG-CoA Reductase Inhibitors - studies in vitro and in vivo

    University dissertation from Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Author : Cristine Skogastierna; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density lipoproteins, is a principle risk factor, but also elevated triglycerides and low levels of high-density lipoprotein cholesterol. READ MORE

  2. 2. Adhesive and signaling mechanisms in abdominal sepsis

    University dissertation from Section for Surgery, Clinical Sciences, Malmö

    Author : Su Zhang; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal sepsis; lung; infection; neutrophil; chemokines; T-cells; HMG-CoA reductase; NFAT;

    Abstract : Sepsis is a major cause of mortality in intensive care units despite decades of scientific efforts. The lung is recognized as the most sensitive and critical organ affected by the hyper-inflammatory response in septic patients. Immune cell dysfunction develops in later phases of sepsis making patients susceptible to infections. READ MORE

  3. 3. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Aliaksandr Bulhak; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Abstract : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. READ MORE

  4. 4. Life Style, Molecular Pathology, and Breast Cancer Risk

    University dissertation from Pathology (Malmö)

    Author : Signe Borgquist; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hormone receptors; Breast cancer; tissue microarray; histopathology; ERβ; tumour proliferation; cyclin D1; p27; HMG-CoA reductas; life style factors; diet; hormone replacement therapy; obesity; endocrine therapy;

    Abstract : The breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. READ MORE

  5. 5. Serum lipoprotein(a) in relation to ischemic heart disease and associated risk factors

    University dissertation from Pathology (Malmö)

    Author : Lisbeth Slunga; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein a ; lipids; epidemiology; coronary artery disease; coronary angiography; HLA DR; acute-phase protein; myocardial infarction; HMG CoA reductase inhibitor; simvastatin;

    Abstract : Lipoprotein(a) (Lp(a)) consists of an LDL-like particle and the specific protein apo(a), which is very similar to plasminogen. Apo(a) contains repeated kringle structures and a serine protease domain, which cannot be activated by t-PA. Lp(a) is considered to be a predictor for atherosclerotic disease. READ MORE