Search for dissertations about: "HMG-CoA reductase"

Showing result 6 - 10 of 19 swedish dissertations containing the words HMG-CoA reductase.

2. 6. Serum lipoprotein(a) in relation to ischemic heart disease and associated risk factors

   Author : Lisbeth Slunga; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein a ; lipids; epidemiology; coronary artery disease; coronary angiography; HLA DR; acute-phase protein; myocardial infarction; HMG CoA reductase inhibitor; simvastatin;

   Abstract : Lipoprotein(a) (Lp(a)) consists of an LDL-like particle and the specific protein apo(a), which is very similar to plasminogen. Apo(a) contains repeated kringle structures and a serine protease domain, which cannot be activated by t-PA. Lp(a) is considered to be a predictor for atherosclerotic disease. READ MORE

4. 7. Studies on N-linked glycosylation in proliferation and viability of normal and tumor cells in vitro

   Author : Magdalena Carlberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Apoptosis; DNA synthesis; IGF-1 receptor; HMG-CoA reductase; lovastatin; mevalonate; N-linked glycosylation; PDGF; SV40-transformation; tumor; tunicamycin.;

   Abstract : A number of studies suggest a critical role of N-linked glycosylation for cellular proliferation. In addition, many transformed and tumor cells have an altered 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and an increased N-linked glycosylation. READ MORE

5. 8. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients

   Author : Carl-Gustaf Hillebrant; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Bile acid synthesis; biliary lipids; cholesterol synthesis; cholesterol 7a-hydroxylase; cholesterol synthesis inhibitor; chenodeoxycholic acid; cholestyramine; 7a-hydroxy-4-cholesten-3-one; HMG CoA reductase; lathosterol; lipoproteins; lithocholic acid; plasma apheresis; ursodeoxycholic acid;

   Abstract : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. READ MORE

6. 9. Requirement for mevalonate-derived lipids in cell proliferation : a study of the role of polyisoprenoid alcohols

   Author : Johan Wejde; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mevalonic acid constitutes a key intermediate in the biosynthesis of a number of isoprenoid products. These metabolites include cholesterol and sterol-derived molecules, but also a large number of non-sterol isoprene derivatives. READ MORE

7. 10. Importance of insulin-like growth factor-1 receptor and EWS/FLI-1 fusion protein in growth and survival of two different types of neuroectodermal tumor cells

   Author : Min Wang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Treatment with comparatively low doses of the 3-hydroxy-3-metylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin caused growth arrest in both melanoma cells and Ewing's sarcoma (ES) cells. In melanoma cells growth inhibition was correlated with a drastic decrease in N-linked glycosylation of the insulin-like growth factor-1 receptor (IGF-1R), which in turn was followed by a decreased expression of IGF-1 binding sites at the cell surface. READ MORE