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Showing result 1 - 5 of 14 swedish dissertations matching the above criteria.

  2. 1. CYTOGENETIC AND MOLECULAR GENETIC CHARACTERIZATION OF LIPOMAS

    Author : Hammurabi Bartuma; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; soft tissue tumors; adipocytic tumors; conventional lipomas; spindle cell lipoma; HMGA2; cytogenetic; molecular genetic; SNP array; GGE;

    Abstract : The focus of this thesis was to study cytogenetic and molecular genetic aberrations in lipomas. For this purpose, chromosome banding analysis, fluorescence in situ hybridization (FISH), as well as high resolution single nucleotide polymorphism (SNP)–arrays were used to identify recurrent chromosomal aberrations in lipomas. READ MORE

  4. 2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    Author : E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. READ MORE

  5. 3. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

    Author : Fredrik Persson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

    Abstract : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. READ MORE

  6. 4. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors

    Author : Maryam K. Afshari; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fusion oncogene; MYB; NFIB; PLAG1; HMGA2; adenoid cystic carcinoma; pleomorphic adenoma; targeted therapy;

    Abstract : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). READ MORE

  7. 5. The genetic basis for adaptation in natural populations

    Author : Sangeet Lamichhaney; Leif Andersson; Carl-Johan Rubin; Alvaro Martinez Barrio; Henrik Kaessmann; Uppsala universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Adaptive evolution; Atlantic herring; ecological adaptation; seasonal reproduction; TSHR; Darwin’s finches; natural selection; beak; ALX1; HMGA2; ruff; lek; inversion; HSD17B2; MC1R;

    Abstract : Many previous studies in evolutionary genetics have been based on few model organisms that can be reared at ease in the laboratory. In contrast, genetic studies of non-model, natural populations are desirable as they provide a wider range of adaptive phenotypes throughout evolutionary timescales and allow a more realistic understanding of how natural selection drives adaptive evolution. READ MORE