Search for dissertations about: "HMGB-1"

Showing result 1 - 5 of 8 swedish dissertations containing the word HMGB-1.

  2. 1. Inflammatory response in equine joints : studies on proinflammatory cytokines in diseased joints and chondrocyte cultures

    Author : Cecilia Ley; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Proinflammatory cytokines mediate inflammatory responses as well as regulate tissue metabolism. Thus, they may provide a link between inflammation and other pathologic findings seen in equine joint disease. READ MORE

  4. 2. On the role of HMGB1 and IL-1 in tissue barrier defense

    Author : Cecilia Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The specialized epithelial surfaces of the lymphoepithelial tissue in the airways and the seminiferous epithelium of the testis are sites of host-environmental interaction at the same time as they serve important physiological functions in gas exchange and reproduction. The host response of a broken epithelial barrier requires rapid mechanisms to control the microflora and to prevent invasion of pathogens. READ MORE

  5. 3. Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine

    Author : Gail E Mullins; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HMGB1; endothelial cells; pro-inflammatory; cytokine; RAGE;

    Abstract : High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic shock in mice. READ MORE

  6. 4. Pathogenic mechanisms in idiopathic inflammatory myopathies

    Author : Cecilia Grundtman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Idiopathic inflammatory myopathies (IIMs) are chronic inflammatory disorders characterized by muscle weakness, by low muscle endurance, and by inflammation in skeletal muscle tissue. The pathogenesis and etiology of these conditions are yet not fully understood and several different mechanisms are likely to be involved. READ MORE

  7. 5. Inflammation in equine articular cartilage : the effect of cytokines in chondrocyte pellets and explants: two in vitro models

    Author : Emilia Svala; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Osteoarthritis (OA) is the main reason for lameness in racehorses. OA is currently clinically diagnosed late in the disease process, when irreversible damages to the articular cartilage have become evident. READ MORE