Search for dissertations about: "HMGB1"

Showing result 11 - 15 of 49 swedish dissertations containing the word HMGB1.

  2. 11. The role of the DAMP molecule HMGB1 in neuroinflammation and macrophage activation

    Author : Henna Salo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : High mobility group box 1 (HMGB1) is a highly conserved nuclear protein expressed in all eukaryotic cells. While its nuclear functions are vital, we know today that HMGB1 also functions as a Damage Associated Molecular Pattern (DAMP). READ MORE

  4. 12. On the role of HMGB1 and IL-1 in tissue barrier defense

    Author : Cecilia Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The specialized epithelial surfaces of the lymphoepithelial tissue in the airways and the seminiferous epithelium of the testis are sites of host-environmental interaction at the same time as they serve important physiological functions in gas exchange and reproduction. The host response of a broken epithelial barrier requires rapid mechanisms to control the microflora and to prevent invasion of pathogens. READ MORE

  5. 13. Studies of the immunopathogenesis of arthritis, with an emphasis on the alarmin HMGB1

    Author : Heshuang Qu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dysregulated inflammatory responses are characterized by the excessive release of endogenous inflammatory molecules, which initiate a chain of reactions, including immune cell infiltration, activation, polarization, necrosis, apoptosis and pyroptosis. These changes in cell distribution and status can lead to tissue damage, represented by swelling, pain, redness, heat and loss of function. READ MORE

  6. 14. On the role of HMGB1 and resistin in severe sepsis and septic shock

    Author : Jonas Sundén-Cullberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Severe sepsis and septic shock are serious manifestations of infectious diseases. Mortality ranges from over 30 % in severe sepsis up to 60% in septic shock. Early antibiotic treatment and intensive care are mainstays of therapy, but outside of this, new treatments have only marginally improved survival. READ MORE

  7. 15. Preterm and term cervical ripening : studies on CRH, HMGB1, toll-like receptors, cytokines and matrix metalloproteinases

    Author : Aurelija Dubicke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical fibroblasts; cervical ripening; cervix; chemokines; cytokines; CRH; HMGB1; interleukin; labor; preterm; preterm labor; matrix metalloproteinases; pregnancy; PPROM; Tolllike receptors;

    Abstract : Objective: Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. Despite the existing treatment, the frequency of PTB has not changed in the past thirty years. Incomplete understanding of the biological and pathophysiological mechanisms underlying preterm delivery is the major obstacle to preventing PTB. READ MORE