Search for dissertations about: "HMGB1"
Showing result 6 - 10 of 49 swedish dissertations containing the word HMGB1.
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6. Danger within : HMGB1 as a mediator of arthritis
Abstract : Chronic arthritis occurs in childhood as juvenile idiopathic arthritis and in adults most commonly as rheumatoid arthritis. The clinical expression of these diseases differ and it is presently unknown to what extent they share pathogenic mechanisms. Optimal modes of therapy in adults generally coincide with those in children. READ MORE
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7. Multiple roles of HMGB1 in clinical and experimental arthritides
Abstract : Inflammation can be infectious and/or sterile depending on the initiating event. The proinflammatory mediator High mobility group box protein 1 (HMGB1) is a nuclear protein released from cells during both sterile and infectious inflammation and once extracellular, initates and potentiates inflammation by inducing cytokine production and by recruiting inflammatory cells. READ MORE
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8. Role of spinal and peripheral HMGB1 in arthritis-induced pain
Abstract : Chronic pain is one of the most debilitating and repeatedly reported symptoms by rheumatoid arthritis (RA) patients. Despite good disease control achieved with disease modifying antirheumatic drugs (DMARDs), joint pain remains a major problem for a subgroup of patients. READ MORE
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9. Following the white rabbit : release and regulation of HMGB1 in inflammation
Abstract : Dysregulated inflammatory responses are characterized by excessive release of endogenous pro-inflammatory molecules, danger-associated molecular patterns (DAMPs). A prototypical DAMP, High Mobility Group Box 1 protein (HMGB1), is primarily bound to DNA in the nucleus of most eukaryotic cells. READ MORE
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10. Life after intensive care-post : intensive care syndrome, inflammation, and HMGB1
Abstract : Survival rates of intensive care unit (ICU) patients are consistently increasing. This new patient population has recently gained increased recognition as they suffer from psychological, physical, and cognitive impairments in the years to come after ICU discharge. READ MORE