Search for dissertations about: "HO-1"

Showing result 1 - 5 of 15 swedish dissertations containing the word HO-1.

  2. 1. Tumor instructed normal tissue : studies of potential extratumoral biomarkers and therapeutic targets in prostate cancer

    Author : Maria Nilsson; Sofia Halin Bergström; Anders Bergh; Kristian Pietras; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; biomarkers; tumor-instructed normal tissue; extra cellular matrix; macrophages; LOX; HO-1; MSMB; Pathology; patologi;

    Abstract : Prostate cancer is the most common cancer in men in Sweden and but luckily the majority of the patients will carry on their life without any consequences from the disease. Unfortunately, some will develop aggressive tumors and eventually die. READ MORE

  4. 2. Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies

    Author : Andreas Hedblom; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; genotoxic damage; cell cycle; leukemia; heme oxygenase; differentiation;

    Abstract : Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. READ MORE

  5. 3. Macrophages, Nitric oxide synthases and Heme oxygenases: possible roles during peripheral nerve regeneration

    Author : Sofia Magnusson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; satellite cells; peripheral ganglia; cell signalling; nerve regeneration; heme oxygenase; Macrophages; nitric oxide synthase; Animal physiology; Djurfysiologi;

    Abstract : The purpose of this study was to investigate the suggestions that macrophages, and the systems generating nitric oxide (NO) and carbon monoxide (CO), i.e. nitric oxide synthases (NOS) and heme oxygenases (HO), could be important for peripheral nerve regeneration. READ MORE

  6. 4. Renal Ischemia/Reperfusion Injury in Diabetes : Experimental Studies in the Rat

    Author : Jan Melin; Bengt Rippe; Uppsala universitet; []
    Keywords : Medical sciences; diabetes mellitus; ischemia reperfusion; rat; end-stage renal disease; inflammation; fibrosis; hyaluronan; CD44; treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Diabetes mellitus (DM) is one of the leading causes of end stage renal failure. An increased susceptibility to renal ischemia/reperfusion (I/R)-injury was found in DM rats. Unilateral renal ischemia for as short as 20 minutes led to an irreversible progressive injury in DM kidneys, whereas the injury in non-DM kidneys was almost reversible. READ MORE

  7. 5. Mechanistic studies of APR-246 in leukemia

    Author : Dina Mahmoud Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. READ MORE