Search for dissertations about: "HPLC high-performance liquid chromatography for two drugs"
Showing result 1 - 5 of 8 swedish dissertations containing the words HPLC high-performance liquid chromatography for two drugs.
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1. Development and Validation of HPLC Methods for Analytical and Preparative Purposes
Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE
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2. Aspects of Optimisation of Separation of Drugs by Chemometrics
Abstract : Statistical experimental designs have been used for method development and optimisation of separation. Two reversed phase HPLC methods were optimised. READ MORE
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3. From achiral to chiral analysis of citalopram
Abstract : Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. READ MORE
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4. Amine transaminase: Process development aspects for chiral amine synthesis
Abstract : Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. READ MORE
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5. Detection and Structure Elucidation of Drug Metabolites in Biological Samples using HPLC-MS/MS Techniques
Abstract : This thesis describes the structure elucidation of drug metabolites in biological samples by the use of high performance liquid chromatography (HPLC) atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). Due to their different advantages, various mass analyzers have been used in the different experiments. READ MORE