Search for dissertations about: "HR functions"

Showing result 1 - 5 of 15 swedish dissertations containing the words HR functions.

  2. 1. Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination

    Author : Jingjing Zhang; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; meiosis; DSB; cancer; BRCA2; MEILB2; BRME1; HR; RAD51; DMC1; DDR;

    Abstract : Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ensures chromosome segregation. Breast cancer susceptibility gene 2 (BRCA2) is a potent cancer suppressor and is required for DSB repair by homologous recombination (HR) in mitosis. READ MORE

  4. 2. Studies of cohesin functions in the yeast and human DNA damage response

    Author : Elin Enervald; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly recognize, signal and subsequently repair DNA damages is crucial. READ MORE

  5. 3. DNA double-strand break repair in ascomycetes

    Author : Jiang Chen; Stefan Åström; Michael Lisby; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; utvecklingsbiologi; Developmental Biology;

    Abstract : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. READ MORE

  6. 4. Structural maintenance of chromsomes : a complex tale of genomic integrity

    Author : Hanna Betts Lindroos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Genomic integrity is an absolute requirement for cell survival. Programmed events such as genome rearrangements and DNA replication can cause lesions in the DNA, as can exogenous agents such as radiation and chemicals. One of the most austere types of lesion is DNA double strand breaks (DBSs). READ MORE

  7. 5. WRAP53β and scaRNA2 on their journey to repair the DNA

    Author : Christos Coucoravas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and its very high affinity for the scaRNAs could implicate these molecules in similar biological functions. READ MORE