Search for dissertations about: "HSV-1"

Showing result 21 - 25 of 33 swedish dissertations containing the word HSV-1.

  2. 21. On Monomeric and Trimeric dUTPases. Recombinant Expression, Purification, Conformational Properties and Catalytic Characteristics

    Author : Rebecca Persson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolism; dUTP; dUTPase; nucleotide metabolism; retrovirus; crystallography; herpesvirus; Biokemi; Biochemistry;

    Abstract : Nucleotide metabolism and replication of nucleic acids are processes of fundamental importance. A crucial enzyme in nucleotide metabolism is dUTPase (E.C. 3. READ MORE

  4. 22. Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy

    Author : Johan Lindström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; herpesviruses; central nervous system; facial paralysis; cerebrospinal fluid; biomarkers; acyclovir; neurotoxicity; syndromic testing;

    Abstract : Abstract Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal tissue and may cause infections in the central nervous system (CNS). READ MORE

  5. 23. Glycoprotein G of Herpes simplex virus type 2. Antigenicity and genetic variability

    Author : Jan-Åke Liljeqvist; Göteborgs universitet; []
    Keywords : Herpes simplex virus type 2; glycoprotein G; antigenic regions; sequence variability;

    Abstract : Herpes simplex virus type 2 (HSV-2) causes genital lesions, meningitis and occasionally, severe neonatal infections. Globally HSV-2 infection is one of the most common sexually transmitted diseases. READ MORE

  6. 24. Strategies to optimize natural killer cell functions in the tumor microenvironment

    Author : Katharina Helene Susek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer (NK) cell-based therapies are employed in early phase clinical trials. READ MORE

  7. 25. Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors

    Author : Xinyu Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells and subsequent treatment with ganciclovir is one of the most commonly studied strategies of suicide gene therapy. READ MORE