Search for dissertations about: "HTR2A"

Showing result 1 - 5 of 7 swedish dissertations containing the word HTR2A.

  2. 1. 5-HT2A : a serotonin receptor with a possible role in joint diseases

    Author : Anders Kling; Solbritt Rantapää-Dahlqvist; Carl-Olav Stiller; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 5-HT2A serotonin receptor; serotonin; rheumatoid arthritis; adverse drug reaction; HTR2A; glucocorticoids; klinisk farmakologi; Clinical Pharmacology;

    Abstract : BackgroundSerotonin (5-HT), an amino acid derivative and neurotransmitter, has for long been studied in relation to inflammation. It is an endogenous ligand for several different types of serotonin receptors. The serotonin receptor 5-HT2A has been reported to have a role in the pathophysiology of arthritis in animal experiment models. READ MORE

  4. 2. On Neuroimmunology and Brain Function: Experimental and Clinical Studies

    Author : Nina Strenn; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune system; mental disorders; polymorphisms; depression; autism; bipolar disorder; SSRI; S100B; 5-HTR2A; Flinders sensitive line;

    Abstract : The immune system has been implicated in the mechanisms underlying many psychiatric disorders. Immune mediators are expressed in the central nervous system (CNS) not only in response to harmful stimuli, but also in a constitutive manner, and serve as important plasticity factors during development. READ MORE

  5. 3. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE

  6. 4. Genetic studies of depressive symptoms

    Author : Mårten Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Depressive Symptoms; Twin; Heritability; Serotonin receptor 2A; Serotonin transporter; MAOA; MAOB; Thrombocyte MAO activity; Linkage Disequilibrium.;

    Abstract : This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. READ MORE

  7. 5. Novel insights into the role of serotonin in control of β-cell fuction

    Author : Hedvig Bennet; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. READ MORE