Search for dissertations about: "HTR2C"

Showing result 1 - 5 of 6 swedish dissertations containing the word HTR2C.

  2. 1. Influence of serotonin-related genes on behavior and body weight

    Author : Jessica Bah Rösman; Göteborgs universitet; []
    Keywords : Serotonin; Genes; anorexia nervosa; premenstrual dysforia; body weight; suicide; polymorphism; HTR2C; SLC6A4; GATA2; HTR3B;

    Abstract : Rationale: The neurotransmitter serotonin has been implicated in the regulation of normal behaviors, including food intake, and attributed importance for a variety of common psychiatric conditions, including major depression, suicidal behavior, eating disorders and premenstrual dysphoria. The purpose of these studies was to explore the possible influence of genetic variation in serotonin-related genes on a) body weight, b) binding capacity of the serotonin transporter in the brain of suicide attempters and c) a disorder for which numerous findings suggest serotonin to play a key role, i. READ MORE

  4. 2. Finding Genes for Schizophrenia

    Author : Karolina Åberg; Elena Jazin; Eva Lindholm; Eric Sobel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; psychiatric genetics; QKI; large pedigree; haplotype investigation; mRNAexpression; genetic linkage; myelin; HTR2C; Biology; Biologi;

    Abstract : Schizophrenia is one of our most common psychiatric diseases. It severely affects all aspects of psychological functions and results in loss of contact with reality. No cure exists and the treatments available today produce only partial relief for disease symptoms. READ MORE

  5. 3. High-resolution Studies of mRNA Expression in Brain : A Search for Genes Differently Expressed in Schizophrenia

    Author : Anja Castensson; Elena Jazin; Terence Speed; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mRNA; gene expression; real-time RT-PCR; schizophrenia; 5-HT serotonin receptor 2C; brain; psychiatric genetics; Genetik; Clinical genetics; Klinisk genetik;

    Abstract : Gene expression differences between patients and controls can be used to find susceptibility genes and drug targets for a disease. High-resolution strategies are required because the differences between the investigated groups may be small and numerous factors may affect the mRNA quantity. READ MORE

  6. 4. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE

  7. 5. Comparative sequencing of candidate genes in complex disease

    Author : Shane McCarthy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA; Sequencing; Complex Disease; Candidate Gene;

    Abstract : Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association studies are increasingly viable alternatives to linkage approaches in locating disease genes. READ MORE