Search for dissertations about: "HUH 7"
Found 4 swedish dissertations containing the words HUH 7.
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1. Metabolic and pharmacokinetic study to enhance busulphan therapeutic efficacy
Abstract : Busulphan (Bu) is an alkylating agent used in high-doses as part of the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). HSCT is a curative treatment for hematological malignancies and other disorders. Bu can be administered by oral or intravenous route. READ MORE
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2. Endotoxin-, glutamate- and drug-induced inflammation and cytotoxicity with emphasis on signal transduction mechanisms
Abstract : Inflammatory cells such as monocytes and glial cells play an important role in the pathogenesis of ischemic- or drug-induced brain or liver injury. Excessive concentrations of glutamate is toxic to neural cells, and triggers a series of transcriptional events beginning with the expression of the immediate early genes like c-fos and c-jun, which in turn affect the expression of other genes necessary for the development of brain injury. READ MORE
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3. CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation
Abstract : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to significantly affect the individual drug response. READ MORE
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4. Peroxisome proliferator-activated receptor delta (PPARD) : molecular studies of regulation and activation
Abstract : The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, PPARG and PPARD. READ MORE
