Search for dissertations about: "Haematology"

Showing result 21 - 25 of 70 swedish dissertations containing the word Haematology.

2. 21. Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes

   Author : Thoas Fioretos; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CRKL; CRK; ABL; BCR; acute lymphoid leukemia; chronic myeloid leukemia; Philadelphia chromosome; Molecular Genetics; Cytogenetics; IFN-alfa; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Abstract : In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positive acute lymphoid leukemia (ALL). READ MORE

4. 22. Diamond-Blackfan Anemia: Erythropoiesis Lost in Translation

   Author : Johan Flygare; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; RNA interference; Erythropoiesis; Lentiviral vectors; Nucleolus; Diamond-Blackfan anemia; Gene therapy; extracellulära vätskor;

   Abstract : Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents as macrocytic anemia during infancy. Linkage analysis suggests that at least four genes are associated with DBA of which two have been identified so far. READ MORE

5. 23. Clinical and Genetic studies in Chronic Myeloid Leukaemia

   Author : Hjalmar Flygt; Ulla Olsson Strömberg; Stina Söderlund; Lucia Cavelier; Jane Apperley; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Chronic Myeloid Leukemia; Medicinsk vetenskap; Medical Science;

   Abstract : This thesis explores strategies to enhance deep molecular response (DMR) rates and treatment-free remission (TFR) eligibility in chronic myeloid leukaemia (CML), investigates factors linked to treatment milestone failures, describes tyrosine kinase inhibitor (TKI) discontinuation outcomes in a population-based cohort, and examines TFR probabilities after a second TKI discontinuation. In paper I we examined data from the Swedish CML registry on 128 CML patients in chronic phase with a reported TKI discontinuation of ≥1 month due to DMR. READ MORE

6. 24. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

   Author : Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

   Abstract : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. READ MORE

7. 25. Biosynthesis, Processing, and Sorting of Human Neutrophil Granule Proteins. Focus on Cathepsin G, Proteinase 3, and Azurocidin

   Author : Daniel Garwicz; Avdelningen för hematologi och transfusionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; differentiation; bone marrow progenitor cells; preproform; mutations; Cell lines; transfection; extracellulära vätskor;

   Abstract : The neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. READ MORE