Search for dissertations about: "Hanna K Nyblom"

Found 1 swedish dissertation containing the words Hanna K Nyblom.

2. 1. Glucotoxicity in Insulin-Producing β-Cells

   Author : Hanna K Nyblom; Peter Bergsten; Michael Welsh; Miriam Cnop; Uppsala universitet; []
   Keywords : Cell biology; type 2 diabetes; SELDI-TOF MS; glucotoxicity; proteomics; insulin secretion; mitochondria; lipids; INS-1E cells; GC-MS; HR-MAS NMR; metabolomics; human islet; AMPK; AICAR; ER stress; apoptosis; Cellbiologi;

   Abstract : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. READ MORE