Search for dissertations about: "Hans Tjälve"

Found 4 swedish dissertations containing the words Hans Tjälve.

  1. 1. Neurotoxic Effects of Dichlorophenyl Methylsulphones Related to Olfactory Mucosal Lesions

    Author : Carina Carlsson; Ingvar Brandt; Hans Tjälve; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Biology; olfcatory toxicity; olfactory bulb; aryl methylsulphone; neurotoxicity; QSAR; Biologi; Biology; Biologi; Ecotoxicology; Ekotoxikologi;

    Abstract : This thesis deals with the highly potent olfactory mucosa toxicant 2,6-dichlorophenyl methylsulphone (2,6-diClPh-MeSO2) and its non-toxic 2,5-chlorinated isomer (2,5-diClPh-MeSO2). In mice, both substances bind firmly in the olfactory mucosa and the olfactory bulb, which are important components of the sensory system. READ MORE

  2. 2. Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

    Author : Veronica Lindström; Ingvar Brandt; Ulrika Bergström; Eva Brittebo; Hans Tjälve; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Toxicology; 3-methylsulphonyl-DDE; o; p -DDD; CYP11B1; adrenal cortex; tissue-specific toxicity; bioactivation; kinetics; Y-1 cells; Toxikologi; Biology; Biologi;

    Abstract : The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy of adrenocortical carcinoma (ACC). READ MORE

  3. 3. Coxsackievirus B3 Infection and Host Defence Responses Change the Metabolism of PBDE

    Author : Magnus Lundgren; Nils-Gunnar Ilbäck; Hans Tjälve; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coxsackievirus; environmental pollutants; PBDE; cytokines; chemokines; metabolism; infection; tissue distribution; toxicology; virology; immunology; Toxicology; Toxikologi; Virology; Virologi; Medicine; medicin;

    Abstract : It has been suggested that the rising amounts of chemicals in the environment may affect host resistance and increase susceptibility to infections. Studies have also shown that infections can change the toxicity of pollutants. READ MORE

  4. 4. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity

    Author : Anna Östergren; Eva Brittebo; Nils Gunnar Lindquist; Anne-Lie Svensson; Hans Tjälve; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

    Abstract : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. READ MORE