Search for dissertations about: "Haplotype"
Showing result 6 - 10 of 249 swedish dissertations containing the word Haplotype.
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6. Studies on warfarin treatment with emphasis on inter-individual variations and drug monitoring
Abstract : Waran används sedan 60 år som blodförtunnande läkemedel för att förebygga eller förhindra progress av blodproppssjukdom. I Sverige behandlas årligen cirka 1 % av befolkningen med waran. I Östergötland uppskattas antal waranpatienter till cirka 3000. Waran hämmar enzymet VKORC1 som ansvarar för vitamin K omsättningen i kroppen. READ MORE
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7. Obesity and Increased Susceptibility : Role of FTO and MGAT1 Genetic Variants
Abstract : Obesity is a complex and a highly individualized disease and the molecular mechanisms behind this disorder need to be better elucidated. Identification of genes and genetic variants that are involved provide opportunities to establish a genetic understanding of the disease. READ MORE
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8. Genome Variation in Human Populations : Exploring the Effects of Demographic History and the Potential for Mapping of Complex Traits
Abstract : A major challenge in human genetics is to understand the genetic variation underlying common diseases. In this thesis, I focus on forces creating differences between individuals and genomic regions, methods for characterizing genomic variation, and the association between genomic and phenotypic variation. READ MORE
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9. Application of Mitochondrial DNA Analysis in Contemporary and Historical Samples
Abstract : The mitochondrion is a tiny organelle that is the power supplier of the cell and vital to the functioning of the body organs. Additionally it contains a small circular genome of about 16 kb, present in many copies which makes the mitochondrial DNA more viable than nuclear DNA. READ MORE
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10. Susceptibility genes in conformational diseases
Abstract : Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent ... READ MORE