Search for dissertations about: "Haplotypes"

Showing result 1 - 5 of 149 swedish dissertations containing the word Haplotypes.

  1. 1. Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations

    Author : Anna Böttiger; Torbjörn Nilsson; Henrik Zetterberg; Örebro universitet; []
    Keywords : AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Folate receptor-alpha; Folate; FOLR1; Haplotypes; Homocysteine; Methylenetetrahydrofolate reductase; MTHFR; Polymorphisms; Pyrosequencing®; SSCP; Medicine; Medicin; Biomedicin; Biomedicine;

    Abstract : Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and neurocognitive disease such as dementia. The B vitamins folate and B12 are the main de terminants of tHcy. tHcy concentration can also be affected by mutations in genes coding for receptors, enzymes and transporters important in the metabolism of Hcy. READ MORE

  2. 2. Intrahepatic cholestasis of pregnancy

    Author : Anna Glantz; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Intrahepatic cholestasis of pregnancy ICP ; pruritus; fetal risk; ursodeoxycholic acid; dexamethasone; ABCB4-gene; haplotypes; sulphated progesterone metabolites;

    Abstract : Intrahepatic cholestasis of pregnancy (ICP) is a condition that has been reported to be associated with an increased fetal risk. A prospective study of ICP was conducted in the Västra Götaland region of Sweden between February 1, 1999 and January 31, 2002. READ MORE

  3. 3. Polyploid Phylogenetics in Plants: Insights on non-model organisms in Fabaceae and Malvaceae

    Author : Jonna S. Eriksson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Diploidization; genome duplication; haplotypes; Hibisceae; Hibiscus; homoeologues; high-throughput sequencing; Pavonia; Malvaceae; polyploidization;

    Abstract : Genome duplication is a common phenomenon in angiosperms and advances in sequencing technologies and bioinformatics is now revealing its prevalence and significance. In a polyploidization event all genes in a genome are doubled. READ MORE

  4. 4. Factors Influencing Evolution to Antimalarial Drug Resistance in Plasmodium falciparum in Sudan and The Gambia

    Author : Amany Kheir; Göte Swedberg; Susanne Kerje; Hamza Babiker; Staffan Svärd; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cross-mating; fitness; microsatellite haplotypes; mosquito infectivity; Infectious diseases; Infektionssjukdomar; Molekylär genetik; Molecular Genetics;

    Abstract : Drug resistance is a major obstacle to management and control of malaria and currently progressing at a rapid rate across Africa. This thesis has examined factors influencing evolution of resistant P. falciparum at two sites in Africa, including parasite migration, cross mating and fitness cost of resistance. READ MORE

  5. 5. MHC polymorphism in a songbird : Fitness, mate choice, and sexual conflict

    Author : Jacob Roved; MEMEG; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; MHC diversity; MHC haplotypes; sexually antagonistic selection; costs of immune responses; adaptive immunity; great reed warbler; songbird;

    Abstract : Sex differences in immune responses have been observed across a wide range of animal species, with the generaltendency that males have weaker immune responses than females. These differences are at least partly caused by immune-regulating effects of sex hormones, and have been associated with an increased prevalence of autoimmune disorders in females and with a general tendency for males to be parasitized more often than females. READ MORE