Search for dissertations about: "Haplotypes"
Showing result 21 - 25 of 158 swedish dissertations containing the word Haplotypes.
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21. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat
Abstract : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. READ MORE
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22. Analysis of HLA-A2 frequency as prognostic and/or risk factors in ovarian cancer patients
Abstract : Major histocompatibility complex antigens are mandatory for the immune response, and genetic imbalance may be linked to tumour escape. The HLA-A2 allele in Scandinavia has a high prevalence; it decreases with latitude and also with ovarian cancer mortality in Europe. READ MORE
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23. Genetics of immunoglobulin a deficiency
Abstract : Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasian populations. It is defined as a serum IgA level below 0.07 g/L with normal IgM and IgG levels in an individual older than four years of age. READ MORE
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24. Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
Abstract : Pharmacogenetics of drug metabolising enzymes has been well studied in Caucasians and Asians, but relatively little in Africans. The aim of this thesis was to investigate the molecular genetics of drug metabolising enzymes, in particular CYP2D6, CYP2C19, CYP2C9, CYP1B1, CYP1A2 and XO, with special emphasis on the Ethiopian population. READ MORE
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25. Evolutionary consequences of dominance at the Brassicaceae self-incompatibility locus
Abstract : Self-incompatibility (SI) is a genetic mechanism that allows plants to enforce outcrossing by rejecting self-pollen and pollen from close relatives. In the Brassicaceae, SI is sporophytic and controlled by the self-incompatibility locus (S-locus). READ MORE