Search for dissertations about: "Haptens"

Showing result 1 - 5 of 12 swedish dissertations containing the word Haptens.

2. 1. In vitro analyses of immune responses to metal and organic haptens in humans with contact allergy

   Author : Khosro Masjedi; Marita Troye-Blomberg; Niklas Ahlborg; Lone Skov; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ELISpot; contact allergy; parthenolide; methylisothiazolinones; nickel; hapten; Allergology; Allergologi; immunologi; Immunology;

   Abstract : Contact allergy is one of the most common skin diseases with great social and economical impact. The origin and nature of contact allergens (haptens) capable of inducing T-cell mediated allergic reactions are diverse, ranging from organic molecules to metal ions. READ MORE

4. 2. Molecular mechanisms and complete antigen formation in allergic contact dermatitis

   Author : Stefan Ahlfors; Lund Dermatologi och venereologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypersensitivity; adduct; immune response.; Allergy; hapten;

   Abstract : Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. READ MORE

5. 3. Analytical methodologies for common skin allergens : Organic thioureas, isothiocyanates and fragrance hydroperoxides in everyday life products

   Author : Ahmed Gamal Ramzi; Ulrika Nilsson; Anneli Julander; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemical analysis; contact allergy; chloroprene rubber; diethyl thiourea; ethyl isothiocyanate; fragrance hydroperoxides; Analytical Chemistry; analytisk kemi;

   Abstract : This thesis describes analytical methodologies for the determination of important skin-sensitizing chemicals in two types of commercial items: chloroprene rubber and fragrance products which are both well-known to be associated with contact allergy.Chloroprene rubber (neoprene) is widely used in different applications and products, such as bags, gloves, wetsuits, braces, mouse pads et c. READ MORE

6. 4. New insights in contact allergy and drug delivery. A study of formulation effects and hapten targets in skin using two-photon fluorescence microscopy

   Author : Carl Simonsson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; contact allergy; cubic phases; cutaneous absorption; bromobimane; isothiocyanate; lipid vesicles; nano; pilosebaceous unit; ; two-photon microscopy;

   Abstract : The skin is a remarkable barrier, protecting us from invasion of e.g. harmful microorganisms and UV-radiation. However, the skin is not adopted to resist repeated exposure to the multitude of xenobiotics introduced into modern society. READ MORE

7. 5. Mass Spectrometry Strategies for Characterization of Contact Allergens and their Protein Conjugates in Vitro and in Vivo

   Author : Lorena Ndreu; Isabella Karlsson; Margareta Törnqvist; Ulrika Nilsson; Maja Aleksic; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Skin allergy; Protein Adducts; In vitro methods; Bioanalysis; Analytical Chemistry; analytisk kemi;

   Abstract : Humans are daily exposed to chemicals from various sources, including cosmetics, jewelry, clothes, and hair dyes, which can result in the occurrence of contact allergy and subsequent allergic contact dermatitis (ACD), a type IV delayed hypersensitivity reaction. ACD is characterized by inflammation and eczema at the site of exposure, and no definitive cure for this condition has been identified to date, with only symptomatic treatment options involving corticosteroids being available. READ MORE