Search for dissertations about: "HbA1c"

Showing result 11 - 15 of 164 swedish dissertations containing the word HbA1c.

  2. 11. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Author : Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. READ MORE

  4. 12. Gestational Diabetes Mellitus - Diagnostic Implications During Pregnancy and Follow-Up

    Author : Rickard Claesson; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gestational diabetes mellitus GDM ; Oral glucose tolerance test; Type-2 diabetes; Diagnostic criteria; HbA1c; Screening test; Follow-up; Body mass index BMI ; Glucose levels; Large for gestational age LGA ; Seasonal variation;

    Abstract : .... READ MORE

  5. 13. Protective factors, health-risk behaviours and the impact of coexisting ADHD among adolescents with diabetes and other chronic conditions

    Author : Charlotte Nylander; Ylva Tindberg; Elisabeth Fernell; Jan Gustafsson; Kristina Berg-Kelly; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adolescent development; adolescent medicine; health behaviour; protective factors; risk-taking; type 1 diabetes; HbA1c; neurodevelopmental problems and ADHD; Medicinsk vetenskap; Medical Science;

    Abstract : Mental health problems are increasing in Swedish adolescents and mortality rates are higher in this age group than among younger. 10-20% of all adolescents suffer from a chronic medical condition (CC). Few protective factors (PF) and clustering of health-risk behaviours (HRB) are frequent among adolescents with CCs. READ MORE

  6. 14. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data

    Author : Gustaf Wellhagen; Maria C. Kjellsson; Bengt Hamrén; Per Olsson Gisleskog; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; modelling; non-linear mixed effects modelling; composite scale data; total score data; total score analysis; precision prediction; bounded integer; bounded integer model; IRT-informed total score analysis; item response theory-informed; mixed models for repeated measures; MMRM; dose-response; dose-response mixed models for repeated measures; DR-MMRM; HbA1c models; fit-for-purpose analysis; clinical trial analysis; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE

  7. 15. Key Features for Successful Swedish Primary Diabetes Care – Reality or Fiction? : Nationwide studies of longitudinal follow-up, HbA1c levels and all-cause mortality in an organizational context

    Author : Rebecka Husdal; Andreas Rosenblad; Janeth Leksell; Eva Thors Adolfsson; Olov Rolandsson; Uppsala universitet; []
    Keywords : Epidemiology; Organization; Personnel resources; Primary health-care; Type 2 diabetes mellitus;

    Abstract : Aims To extend knowledge about the changes in Swedish primary diabetes care from 2006 to 2013 and investigate associations of personnel resources, organizational features and quality-of-work conditions of primary health-care centres (PHCCs) with individual HbA1c levels and all-cause mortality in people with type 2 diabetes mellitus (T2DM).Methods Information about organizational features, personnel resources and quality-of-work conditions were collected from responses of PHCC managers to the Swedish National Survey of the Quality and Organisation of Diabetes Care in Primary HealthCare (Swed-QOP) questionnaire. READ MORE