Search for dissertations about: "Heart in rats"

Showing result 1 - 5 of 72 swedish dissertations containing the words Heart in rats.

  1. 1. Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions

    Author : Martin Hellström; Anna Engström-Laurent; Bengt Johansson; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; CD44; heart; Rat; cardiac hypertrophy; artery; vein; human; Medicine; medicin;

    Abstract : Tissues are not solely composed of cells. The extracellular matrix is important for the cell well-being and cell-cell communication. The glycosaminoglycan hyaluronan (HYA) is a widely distributed extracellular matrix (ECM) component. READ MORE

  2. 2. Autoantibodies in congenital heart block

    Author : Robert Klauninger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Neonatal lupus erythematosus (NLE) affects neonates of Ro/SSA and La/SSB positive women. NLE is associated with several clinical manifestations including skin rash, cytopenia and congenital heart block (CHB). CHB is the most severe manifestation which can develop into a lethal atrioventricular (AV) block. READ MORE

  3. 3. Chiral and toxicological aspects of citalopram : an experimental study in rats

    Author : Fredrik C. Kugelberg; Olav Spigset; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Citalopram (CIT) is a selective serotonin reuptake inhibitor (SSRI), which is used for the treatment of different psychiatric disorders. The indications for prescription of OT are linked to high risks for intentional intoxications. CIT is one of the most commonly found drugs in Swedish forensic autopsy cases. READ MORE

  4. 4. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

    Author : Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE

  5. 5. Endothelium-derived substances and regional hemodynamics in experimental hypertension

    Author : Sven-Olof Granstam; Uppsala universitet; []
    Keywords : Medical sciences; nitric oxide; endothelin; hypertension; rats; SHR; hemodynamics; blood pressure; blood flow; acetylcholine; carvedilol; microsphere method; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The spontaneously hypertensive rat (SHR), a model for experimental hypertension, is considered to have similarities with essential hypertension in humans. Differences between SHR and normotensive Wistar Kyoto rats (WKY) in the vascular response to endothelial-derived substances such as nitric oxide (NO) have been intensively studied in vitro. READ MORE