Search for dissertations about: "Heart in rats"

Showing result 11 - 15 of 73 swedish dissertations containing the words Heart in rats.

2. 11. Pathophysiological role and clinical relevance of cytokines in hypertensive heart failure. A combined clinical and experimental study

   Author : Espen Haugen; Göteborgs universitet; []
   Keywords : Heart failure; cytokines; elderly; hypertension; cardiac remodelling; interleukin 6; etanercept; adiponectin;

   Abstract : Although mortality due to heart failure has decreased significantly in the last decade since the introduction of ACE-inhibitors and ?-adrenergic receptor blockers in the management of heart failure, chronic heart failure is still one of the most important causes of morbidity and mortality and has a very high frequency for readmission to hospitalization because of the aggravation of heart failure. This accounts for a significantly higher health-care expenditure that is twice as much the cost for cancer. READ MORE

4. 12. Dynamics of the glomerular filtration barrier - Physiological and pathophysiological aspects

   Author : Josefin Axelsson; Njurmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glomerular filtration barrier; Glomerular permeability; Microalbuminuria; Albumin; Ficoll; Sieving Coefficient; Rats;

   Abstract : The dynamic properties of the glomerular filtration barrier (GFB) are of fundamental importance for the understanding of the physiology and pathophysiology of microalbuminuria and proteinuric diseases. In the studies of this doctoral thesis the properties of the rat glomerular filtration barrier were investigated under resting conditions and following a number of challenges using highly sensitive gel filtration chromatography (HPSEC) detection of FITC-Ficoll in serum and urine. READ MORE

5. 13. Inhibition of acute allogaft rejection - experimental transplant studies with biological and chemical immunosuppressants

   Author : Zhongquan Qi; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; tacrolimus; MNA; leflunomide; cyclosporine; drug effects; graft survival; immunosuppression; heart; animal; transplantation; Immunologi; serologi; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Abstract : In clinical transplantation immunosuppressive agents are used in combination with the objective to achieve additive effects and less toxicity. A large number of novel drugs are candidates for clinical introduction at this time and experiments in animal models have an important role to play. READ MORE

6. 14. The Role of Angiotensin II in Experimental Acute Kidney Injury and Cardiorenal Failure

   Author : Sofia Jönsson; Michael Hultström; Helle Prætorius Øhrwald; Uppsala universitet; []
   Keywords : Heart failure; Acute kidney injury; Angiotensin II; Fluid balance; Cardiac function; Renal function;

   Abstract : Blood pressure and fluid regulation are kept constant through the interaction between heart and kidneys. When the systemic blood pressure decreases, the levels of the hormone Angiotensin II increase, leading to vasoconstriction and therefore increased blood pressure. READ MORE

7. 15. Congenital malformations in experimental diabetic pregnancy : Aetiology and antioxidative treatment

   Author : Martin Simán; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pregnancy; teratology; malformations; embryo; fetus; cataract; sorbitol; antioxidants; butylated hydroxytoluene; vitamin E; vitamin C; TBARS; neural crest cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Diabetes mellitus in pregnancy causes congenital malformations in the offspring.The aim of this work was to characterize biochemical and morphologic anomaliesin the conceptus of an animal model of diabetic pregnancy. In addition, apreventive treatment against diabetes-induced dysmorphogenesis was developed. READ MORE