Search for dissertations about: "Helder André"

Found 2 swedish dissertations containing the words Helder André.

  2. 1. Analysis of HIF-1alpha degradation and function

    Author : Helder André; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hypoxia-inducible factor-1alpha; protein degradation; prolyl hydroxylases; adenoassociated virus; gene therapy; angiogenesis.;

    Abstract : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. READ MORE

  4. 2. Assessment of HIF-1alpha function and identification of a novel degradation mechanism

    Author : Helder André; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF-1alpha and ARNT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. READ MORE