Search for dissertations about: "Helena Öberg"
Found 5 swedish dissertations containing the words Helena Öberg.
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1. Diatoms in Lake Duluti : Tracking Environmental Variability in Northern Tanzania during the Past 1000 Years
Abstract : The tropics are the regions which are least understood climatically and new data on past climate variability is necessary for reliable future modeling of climate change. This thesis contributes with new paleoenvironmental information from a small crater lake in northern Tanzania and provides an additional link between the integrated history of climate, environment and socioeconomic variability in tropical Africa. READ MORE
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2. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy
Abstract : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. READ MORE
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3. Epigenetic gene regulation in multiple myeloma and mood disorders
Abstract : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. READ MORE
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4. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine
Abstract : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. READ MORE
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5. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation
Abstract : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. READ MORE