Search for dissertations about: "Helena Danielson"

Showing result 16 - 20 of 21 swedish dissertations containing the words Helena Danielson.

2. 16. Accelerating the discovery of drugs for Neglected Tropical Diseases using biophysical methods

   Author : Giulia Opassi; Helena Danielson; Jenny Sandmark; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neglected Tropical Diseases; Drug Discovery; Biochemistry; Biophysics; Kinetic; Fragment Based Lead Discovery; Assay Development;

   Abstract : Even though they account for 10% of the global disease burden and besides the new record of funding in 2018, tropical diseases are still neglected by the majority of pharmaceutical companies and public funding. The reason can be mostly found in the fact that for these diseases a conventional drug discovery process is often too expensive. READ MORE

4. 17. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

   Author : Anton Poliakov; Helena Danielson; Boris Turk; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; Biochemistry; Biokemi;

   Abstract : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. READ MORE

5. 18. Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy

   Author : Christian Seeger; U Helena Danielson; Sarah Lummis; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surface plasmon resonance; biosensor; AMPA receptor; GABAA receptor; ligand-gated ion channel; A-kinase anchoring protein; caldendrin; calmodulin; HIV; fragment based drug discovery; Biokemi; Biochemistry; Neuroscience; Neurovetenskap;

   Abstract : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. READ MORE

6. 19. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

   Author : Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
   Keywords : Biokemi; Biochemistry;

   Abstract : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. READ MORE

7. 20. Interaction kinetic analysis in drug design, enzymology and protein research

   Author : Vladimir O Talibov; U. Helena Danielson; Glyn Williams; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

   Abstract : The work presented here is focused on the phenomenon of molecular recognition – the mutual ability of biological molecules to recognize each other through their chemical signatures. Here, the kinetic aspects of recognition were evaluated, as interaction kinetics reveal valuable dimensions in the description of molecular events in biological systems. READ MORE