Search for dissertations about: "Helena Porsch"

Found 1 swedish dissertation containing the words Helena Porsch.

2. 1. Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling

   Author : Helena Porsch; Paraskevi Heldin; Véronique Orian-Rousseau; Uppsala universitet; []
   Keywords : extracellular matrix; growth factor; hyaluronan synthase; hyaluronidase; epithelial-mesenchymal transition; Molekylär cellbiologi; Molecular Cellbiology;

   Abstract : In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor. Overexpression of the glycosaminoglycan hyaluronan, and its adhesion receptor CD44, correlate with breast cancer progression. READ MORE