Search for dissertations about: "Hematologi"

Showing result 1 - 5 of 148 swedish dissertations containing the word Hematologi.

  1. 1. Processing of TNF-receptors to soluble receptor forms in myeloid cells

    University dissertation from Research Department 2, University Hospital, S-221 85 LUND, SWEDEN

    Author : Flemming Björnberg; Lund University.; Lunds universitet.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation cytokine TNF receptor; extracellular fluids; Haematology; Hematologi; extracellulära vätskor;

    Abstract : TNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. READ MORE

  2. 2. Sorting and processing of neutrophil granule proteins

    University dissertation from Elinor Bülow, Dept of Hematology, C14, BMC, 221 84 Lund

    Author : Elinor Bülow; Lund University.; Lunds universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secretion; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; cell-specific retention; chimeric; lysosome-related organelles; secretory pathway; propeptide of MPO; azurophil granules;

    Abstract : The neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. READ MORE

  3. 3. How can p53 induce differentiation of leukemic cells?

    University dissertation from Department of Hematology, Lund University

    Author : Kristina Drott; Lund University.; Lunds universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; p53-differentiation-p21-WT1-leukemia; Hematologi; Haematology; extracellulära vätskor;

    Abstract : The terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. READ MORE

  4. 4. Characterization of human myeloid progenitors and their differentiation

    University dissertation from Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University

    Author : Louise Edvardsson; Lund University.; Lunds universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; extracellular fluids; Haematology; Medicin människa och djur ; thrombopoietin receptor; hematopoiesis; transcription factors; growth factor receptors; human myeloid progenitors; Hematologi; extracellulära vätskor;

    Abstract : All hematopoietic cells are derived from the hematopoietic stem cells (HSCs) in a continuous and dynamic process, regulated by a network of transcription factors in different combinations and extrinsic signals from growth factors (GFs) and other factors in the microenvironment. In the initial stages of hematopoiesis HSCs differentiate to progenitor cells with gradually more restricted lineage potential and according to the most accepted model the first restriction in developmental potential results in commitment to either the lymphoid or the myeloid branch, in the latter followed by commitment to the neutrophil/monocyte and erythrocyte/megakaryocyte lineages. READ MORE

  5. 5. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    University dissertation from Divison of Hematology and Transfusion Medicine, Lund University

    Author : Ying Gao; Lund University.; Lunds universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Abstract : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. READ MORE